Zofran – AGP

/15

Gastroesophageal reflux

Dyspepsia

Emesis

Gastroparesis

Cause the delicate tissues of the esophagus to tear, or even rupture

Dehydration

Can cause the body’s supply of potassium to increase to dangerously high levels

Disrupt the acidity of the blood

Dopamine

5-HT

Histamine

All of the above

Anesthetics and Opioid analgesics

Motion sickness

Psychological effects

All of the above

5-HT4

5-HT3

5-HT2

5-HT1

Metoclopramide

Promethazine

Ondansetron

Domperidone

16 mg given 1 hour prior to anesthesia

14 mg given 1 hour prior to anesthesia

12 mg given 1 hour prior to anesthesia

10 mg given 1 hour prior to anesthesia

A single dose of 4 mg by slow IV injection (not less than 30 sec) administered at the induction of anesthesia

A single dose of 3 mg by slow IV injection (not less than 30 sec) administered at the induction of anesthesia

A single dose of 2 mg by slow IV injection (not less than 30 sec) administered at the induction of anesthesia

A single dose of 1 mg by slow IV injection (not less than 30 sec) administered at the induction of anesthesia

Pre-ejection, ejection and post-ejection phase

Pre-ejection and post-ejection phase

Ejection and post ejection phase

Pre-ejection and ejection phase

Blockage of the airway/Aspiration

GI Bleeding

Migraine

Stomach Ache

Age over 70 years

History of motion sickness

Chronic renal failure

Male gender

Hyperkalemia

Hypocalcemia

Hyponatremia

Hyperglycemia

Metabolic acidosis

Respiratory alkalosis

Metabolic alkalosis

Respiratory acidosis

Ondansetron

Metformin

Simvastatin

Aspirin

Hypovolemic shock

Hypertension

Hypercalcemia

Hyperlipidemia

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